The metal middle frame with exquisite glass backboard is not only high-end atmosphere, but also particularly textured, which is full of technology in your hand. This color scheme is really amazing. It can show rich and delicate color changes under different light, just like a work of art, which fully meets my high requirements for the face value of mobile phones. The body design of the mobile phone fits the palm of your hand very well, and the grip is great. You won’t feel tired after using it for a long time. The details are handled in place, and the rounded transition at the edge makes the whole more comfortable.

With the increasing number of high-rise residential buildings, secondary water supply has become a problem closely related to people’s livelihood. Recently, some citizens have reported that there is a problem with the secondary water supply in their homes: some homes are empty, but the water meters are turning; Some question that there is a lot of water consumption in the home, but the property cannot be solved; Some people think that the water pressure of secondary water supply in the home is a little low, and hope that the water pressure can be high … The problem of secondary water supply has become one of the hot issues of public complaints.

A citizen who lives in Mulan Garden, Dragon City, Oriental reported that his home is a secondary water supply. In the past, the water used to be normal and the water pressure was high. "The bath is standing far away, and the water from the faucet can also be drenched." However, since the water supply company adjusted the water pressure, the water pressure in the home has become lower. Many residents in the same building have the same confusion, and the water experience is not as good as before. It is suggested that the water supply company adjust the water pressure to the same high as before.

The reporter learned from Huayan in Wuhu that the high water pressure has an impact on the lives of residents in the community! With the change of occupancy rate and water consumption, Wuhu Huayan will adjust the secondary water supply pressure according to the relevant national standards to achieve energy-saving, efficient, time-saving and labor-saving high-rise water supply!

"At this stage, before 2015, most of the secondary water supply facilities and pump rooms in Wuhu City were built and operated by real estate enterprises. After delivery, the operation and maintenance of the secondary water supply equipment were managed by the residential property company. In case of insufficient pressure and increased water charges, the main target of citizens’ consultation and reflection was our water supply company." Wuhu Huayan staff introduced that due to some enterprises’ unprofessional management, poor service, aging facilities unable to maintain, untimely cleaning and disinfection of water tanks (pools), and chaotic use of equipment brands and quality, failures occurred from time to time, which brought hidden dangers to water supply safety. The water supply company does not own the property rights of these secondary water supply facilities, nor is it authorized to manage these equipment, only to ensure that the water is qualified when it enters the community.

In 2015, Wuhu City issued the Measures for the Administration of Secondary Water Supply in Wuhu City and other relevant laws and regulations, requiring that the management of secondary water supply be comprehensively strengthened to ensure the safety of urban water supply. Subsequently, Wuhu Huayan actively participated in the formulation of secondary water supply standards, project construction and handover, and 66 projects have been completed and put into operation. It has played a positive role in promoting the standardization construction of secondary water supply facilities in Wuhu, and also opened a good start for the future work of "unified construction and unified management" of secondary water supply.

The reporter learned that the problems reflected by residents of secondary water supply are mainly in the following aspects:

Is the water pressure of secondary water supply as high as possible?

Some residents may think that the higher the water pressure, the better, which is more comfortable to use. In fact, there is an upper limit on the pressure of water supply pipeline. If the pressure of water supply is too high, it will do great harm to pressurizing equipment, water supply equipment and water consumption equipment. According to the standard of Technical Specification for Secondary Water Supply Project in Anhui Province, the pressure of the lowest-level household pipe in each partition should not exceed 0.35Mpa. If the community supplies water with ultra-high pressure for a long time, it will cause great harm.

Water supply exceeding the design pressure will not only lead to the long-term overload operation of the pressurized water pump and increase the power consumption (increase the owner’s share of electricity), but also the pressurized related equipment (water pump, check valve, connector, butterfly valve, etc.) will be easily damaged. Long-term ultra-high pressure water supply, the pressure of water supply pipeline exceeds the design value, which is easy to cause water leakage and damage of water supply equipment pipeline (especially pipeline joints and bends in weak links), and increase the phenomenon of leakage and pipe explosion. On the one hand, it will often stop water maintenance, affect residents’ lives, on the other hand, it will also cause water waste and increase the water sharing of residents. Because the water pressure requirements of household sanitary wares and household appliances are designed according to national standards, the long-term high water pressure of households will also lead to the damage of the toilet bowl, affect the service life of water heaters and faucets, and the household water consumption will also exceed the normal range, resulting in an increase in electricity bills.

I am away from home for a long time, why does the water meter generate expenses?

This is because there is air in the water pipe due to the pressure of the pipe mixed with air and the change of water temperature, and the pulsation effect caused by it makes the water meter installed in some positions slowly move when there is no running water. Wuhu Huayan suggested that users should contact the management unit of secondary water supply to help close the valve before and after the water meter, so as to avoid idling of the water meter.

Why does my home use secondary water supply on the fifth floor?

This is designed according to the actual situation of the developer in the early stage of construction, which may be caused by the high floor height, high terrain and low local water pressure.

Is the water quality of secondary water supply guaranteed?

Since the promulgation of the Measures for the Administration of Secondary Water Supply for Urban Residential Buildings in Wuhu City in 2015, according to the relevant regulations, the secondary water supply management unit needs to clean the secondary water supply tank every quarter, and the health and epidemic prevention department needs to conduct random inspections and issue relevant water quality test reports.

　　According to the current policy, renting a house can apply for points admission, but the landlord needs to cooperate with the street rental office to apply for a lease certificate, which is commonly known as a lease contract. However, many parents are stuck by this certificate because the landlord does not cooperate. Today, some citizens reported that some landlords were willing to cooperate, but the asking price was outrageous.

　　Dapeng points lowland citizens go to rent houses.

　　Ms. Zhou, who lives in Longgang, said that her child will go to primary school next year. According to the current regulations, she needs to apply for a lease contract before April 1 this year, and her child will be able to go to school normally next year. However, she is not a deep household but also a point for renting a house. The surrounding schools generally need more than 70 points. Obviously, her points can’t be a good school. So she turned her attention to Shenzhen School, a high school affiliated to the National People’s Congress in Dapeng New District.

　　The new school is popular, and the rent has soared.

　　Shenzhen School attached to the National People’s Congress is a school that was put into use only in 2017. There are not many students around, so the score is relatively low. According to Ms. Zhou’s points, children will definitely be able to attend school. Everything is ready except for renting a house, so Ms. Zhou chose one of the rented houses at the beginning of this year.

　　Can only rent for a long time and ask for 80 thousand

　　Ms. Zhou said that because the house has a degree, the owner thinks that if Ms. Zhou is allowed to use this degree, it means that the house will be locked in a six-year degree. Therefore, not only the price increase, but also the long-term rent, the rent for two years at a time, this account is counted. Let Ms. Zhou’s heart cool.

　　The rent has all gone up, including the degree fee

　　Ms. Zhou said it was really difficult for her to take out so much money at one time. Ms. Zhou thought that he was not the only degree room in Shenzhen School affiliated to the National People’s Congress, so she continued to look for other houses, but she didn’t expect the rents around her to rise in just half a month.

　　Blank houses are also rented for six years and sixty thousand yuan.

　　Ms. Zhou said that it is not an individual phenomenon that the high-priced rental degree is near the Shenzhen School affiliated to the National People’s Congress. The owners even have a unified market price. Recently, there has also been a phenomenon of renting blank houses. As the name implies, blank houses can’t live in people, but the rent is 10 thousand yuan a year, and it will be 60 thousand after six years.

　　A number of real estate degrees have been rented out.

　　Later, the reporter went to a housing agency near the school. The staff introduced that the additional fee for degree rooms is a tacit understanding recently formed by the owners. The price has gone from a few thousand yuan at the beginning to 11,000 years now, and the rough houses are already in short supply, and they are all rented out but not occupied. The Shenzhen School affiliated to the National People’s Congress, which originally had few students, suddenly became lively.

　　In the past, we often heard about sky-high degree rooms, all of which were about buying degree rooms. It is very rare to rent a degree room at such a high price. After all, it is basically difficult to apply for a good degree and rent points. However, it happened that this abnormal phenomenon occurred in Shenzhen School affiliated to the National People’s Congress in Dapeng New District. Should the relevant departments take care of it?

　　An agreement before renting a house can reduce disputes

　　Lawyers believe that the degree room includes housing points and rental points, which are in conflict, which means that once the degree room is locked for six years in the name of renting, it is equivalent to occupying the owner’s degree in buying a house. Therefore, when the tenant and the owner sign the rental contract, they should clearly agree on the use of the degree in advance, and the owner will get some extra compensation, which is legally protected.

　　Beware of price war, the government should intervene.

　　In real life, many tenants have not agreed with the owners in advance. After renting, they find that they need a degree, so they are prone to conflicts. At present, laws and regulations have not made clear provisions, so they can only solve them through consultation. The lawyer pointed out that in either case, it is reasonable for the degree price to be adjusted according to market rules without legal prohibition, but the price war in special areas should be prevented.

　　The government should strengthen the verification of the degree of renting blank houses

　　The survey found that some owners priced their rental houses and degrees separately, which caused a lot of chaos. For example, the previous "First Scene" survey showed that an intermediary collected money to help people handle the lease contract, so that students who had not rented in the area were eligible to enroll in the school. In the neighborhood around Shenzhen School affiliated to the National People’s Congress, some owners sell rough houses, and the actual houses are uninhabited. The education department and the leasing department should strengthen supervision.

　　Post-event household verification should make a difference.

　　Lawyers, on the other hand, believe that it is reasonable for the leasing office to relax its control on the premise that the registration of housing lease contracts is not mandatory. Therefore, in the follow-up verification, it is necessary for all departments to jointly plug the loopholes, so that the actual renter can obtain the qualification to enter the school nearby. According to the current regulations, it takes one year for the lease contract to participate in the points, and during this year, the street office should do a good job of verification.

Recently, it unveiled its second model, Dongfeng Yipai eπ 008, which is positioned as a "family intelligent large SUV". It has a length of 5002mm, a wheelbase of 3025mm, and a 6-seat home layout of "2 + 2 + 2". The excellent body size makes Dongfeng Yipai eπ 008 have very strong space attributes, making it a veritable "536" model. In this regard, we have also had a test drive experience of the vehicle and share with you some of the experience after the test drive.

In the actual test drive, the eπ 008 has three modes: pure electric priority, fuel priority, and mixed gasoline and electricity. The power response is still very positive, and it is more suitable for household use. It is recommended to drive pure electric priority in daily cities. While saving energy and being cost-effective, you can also enjoy the light driving experience brought by the tram.

When passing through the fine and bumpy road section, the filter of Dongfeng Yipai Eπ 008 is relatively in place, and it is generally comfortable. In steering, although driving such a big guy, the steering is still very flexible and not clumsy.

The NVH performance of the new car is also good. The eπ 008 uses 265/45 R21 size Continental silent tires. When driving on the gravel road at a speed of 90km/h, the noise in the car is about 75.8dB. When driving on high-speed sections, the wind noise control is good, and the wind sound is hardly audible. However, the tire noise of the vehicle is slightly obvious, which may be caused by the large tire width.

After saying dynamic, look at static

From the appearance, the EPi 008 adopts a closed front face design, which is also one of the popular features of the moment. The entire front part looks very sturdy, giving a very heavy feeling. The through light strip divides the front face into two, and there is a relatively complex built-in light source inside, which can support a variety of lights when lit, especially at night to create a very cool atmosphere.

On the side of the body, it is worth mentioning that there is also a small window between the C-pillar and the D-pillar, which can make the third-row passengers not feel depressed. In addition, the D-pillar is also equipped with a digital rhythm charging indicator light, which will produce different light changes when the vehicle is charging. In terms of body size, the length, width and height of the Dongfeng Yipai e π 008 are 5002mm × 1972mm × 1732mm, the wheelbase is 3025mm, and the positioning of the medium and large SUV is 0.268Cd.

At the rear of the car, the eπ 008 also uses a through-type taillight, and the internal lattice light source shape echoes the front of the car, which is highly recognizable after lighting.

Entering the car, the interior of the eπ 008 continues the interior design style, which is as windy as the appearance. Although the shape is simple, the texture is online. The six-seat layout of 2 + 2 + 2 will be more suitable for large families and can take care of everyone’s comfort.

Intelligent configuration,E π 008The intelligent cockpit is composed of an 8.8-inch instrument and a 15.6-inch central control screen. The car is the mainstream chip, and the impression I get from using it is that the screen is large, the car responds quickly, and the mainstream functions can be found quickly. The voice system responds quickly, and it can be 100% voice-controlled on the car-machine interface. The overall experience does not differ much from other models.

In terms of space, adjust the second row of seats to the final state. After riding with a height of 170cm, there is still room for more than 3 punches in the legs. After adjusting the second row to the remaining 2 punches, the third row of legroom also has 3 fingers of wealth. When 6 people travel at the same time, the third row is more suitable for passengers with a height of less than 175cm.Among them, you can also choose seats, leg supports, small table boards, headrests, and sunshades on the right side, which are all equipped with rich functions.

Write to the end

As a medium and large SUV, the Eπ 008 shows excellent competitiveness in terms of appearance, interior, comfort, power and intelligent configuration. The price of the 216,600 is also relatively close to the people. Recently, there are preferential policies, and the price of the limited-time car starts from 18,86 yuan. Interested friends can go to the store for a test drive and learn about your local preferential situation by the way.

　　Food and nutrition, as one of the brilliant cultural achievements of the Chinese nation, has taken root and sprouted in this land since ancient times and has been passed down to this day. The history of feeding can be divided into two stages: the first stage is the enlightenment and growth stage before the Tang Dynasty; The second stage is the stage of development, maturity and prosperity after Sun Simiao first put forward the theory of dietotherapy in Tang Dynasty. However, after the introduction of western medicine and nutrition into China, the concepts of food support and dietotherapy seem to become more and more vague, and their application is also confusing, lacking effective guidance. In order to trace the source and use it in order, today we mainly talk about the problem of food support before the Tang Dynasty from a historical perspective. Based on this, what we refer to as food and medicine refer to substances that have traditional usage habits and history in China, so medicine naturally refers to Chinese medicine or Chinese herbal medicines.

　　First, what is food support

　　According to the Book of Rites, as early as the Zhou Dynasty, there were full-time food doctors in the palace, whose main duty was to provide reasonable diet and nutrition for the Zhou royal family.

　　The word "feeding and nourishing" first appeared in the "On the Five Permanent Political Powers" in the Yellow Emperor’s Classic of Internal Medicine (hereinafter referred to as the "Classic of Internal Medicine"), and it said: "The disease is new for a long time, and it is toxic and non-toxic, so it is appropriate to make it regular. Great poison cures diseases, and ten goes to the sixth; Often poison cures diseases, and ten goes to the seventh; A small poison cures a disease, and ten goes to eight; Non-toxic treatment, nine out of ten. Grain, meat, fruits and vegetables are exhausted, and they are not used to it, which hurts them. "

　　Traditional Chinese medicine believes that a healthy human body should be in a state of yin and yang balance, and illness is the reason for the imbalance of yin and yang. Medication mainly relies on the bias of drugs (some of which are toxic) to intervene in the human body in order to achieve a re-balance between yin and yang. If some drugs are cold, they can treat heat syndrome; Some drugs are too hot to treat cold syndrome. This is what Chinese medicine often says: "those who are cold are hot, and those who are hot are cold." Since drugs are obviously biased, even if they are not toxic, they are not suitable for long-term use without the guidance of doctors. For example, Cordyceps sinensis is a good thing and has no toxicity, but not everyone can eat it. Even the same person is suitable for eating today, but it may not be suitable for eating after a while. Nowadays, many people always think that Chinese medicine is very safe, and it is very wrong to eat it at random without the guidance of a doctor.

　　The quotation in the above-mentioned Neijing holds that medication should not be used too much, and it should stop at the stage of "healing" when the disease is cured, and use "food support" for recuperation and rehabilitation. This is to carry out rehabilitation work by choosing food with relatively more peaceful taste instead of medicine. Why do you want to do this? Neijing holds that "it hurts the righteousness". That is, I am afraid that it will hurt the healthy qi of the human body. According to modern theory, it is afraid that it will hurt the immunity and resistance of the human body. This is the source of food and nutrition.

　　Therefore, we must make it clear that the so-called food cultivation is a method to prepare corresponding food for human consumption through selecting appropriate ingredients, reasonable collocation and appropriate cooking and production methods, so as to recuperate the healthy qi of human body.

　　Second, the connotation of food support

　　As mentioned in the above quotation, when drugs are used to treat diseases, whether toxic or non-toxic, they should stop when the disease has gone to its sixth, seventh, eighth and ninth, and use more peaceful food instead of drugs to complete the aftercare work. I am afraid that if drugs are used blindly, even if they are non-toxic, their bias will damage the healthy qi of the human body. Therefore, the first aspect of the connotation of food and nutrition is the embodiment of the traditional Chinese medicine’s thought of "stopping the disease in the middle" and "eliminating evil without hurting righteousness" We modern people are always anxious to see the disease well, but often fall into the situation of overtreatment without knowing it. It is sad that children are eager to use antibiotics to reduce their fever as soon as they have a fever, so as to reduce their parents’ own worries and troubles.

　　There is a saying in the article "On the Time of Dirty Qi Method" in Neijing Su Wen: "Poison attacks evil, grains feed, five fruits help, five animals benefit, five dishes are filled, and the smells are combined to supplement lean qi."

　　Five grains, five fruits, five livestock and five vegetables are all foods. When they are used reasonably and balanced in nutrition, they can achieve the effect of replenishing essence. Supplementing essence and qi belongs to the category of "strengthening the body" mentioned by traditional Chinese medicine. "Eliminating pathogenic factors" and "strengthening body resistance" are the main methods of treating diseases in traditional Chinese medicine. The so-called eliminating pathogenic factors means using the partiality of drugs to eliminate pathogenic factors in the body, just like marching to fight, which means expelling the enemy from the country; The so-called righting means mainly using some drugs with tonic effect to support and cultivate healthy qi in the body, which means strengthening the strength of one’s own army. From the interpretation of Neijing, the righting can be done not only by drugs, but also by reasonable diet. Therefore, the second connotation of food support is the embodiment of the thought of "strengthening the body" in traditional Chinese medicine.

　　Third, the content of food support

　　Through the interpretation of Neijing and related classics, food and nutrition is still a guiding principle of traditional Chinese medicine, that is, the three-factor diet recuperation methods and dietary taboos due to people, time and place. The so-called "because of people" is based on individual’s different physique or illness; The so-called timing is based on different seasons or times; The so-called place is based on different regions or environments.

　　The content of food and nutrition mainly includes three parts: food suitability, food taboo and food and nutrition prescription.

　　The so-called food suitability refers to deciding what to eat, what ingredients to choose, what processing methods to use, etc. according to the above-mentioned three-cause principle, in order to maintain or recuperate the body to a healthy state of yin and yang. This part of the content has long been systematically expounded in Neijing, such as different foods suitable for eating according to seasons and different dietary guidance according to diseases.

　　On the issue of ingredients, we must point out that many people like to add some Chinese herbal medicines to their food. For safety reasons, please be sure to look for them in the list of 87 "dual-use" Chinese herbal medicines published by the National Health and Family Planning Commission.

　　About food taboos, it is also a dietary taboo based on personal health according to the guiding principles of the above three reasons. Generally speaking, food taboos generally refer to all dietary taboos, including those in healthy state, food dosage, food quality (i.e. whether it goes bad or not), food collocation and diseases. Dietary taboos during illness, commonly known as taboos, are mostly recorded in prescriptions of past dynasties.

　　As early as the Eastern Han Dynasty, there were a large number of books on food classics in China (unfortunately, most of them were lost), and some food-nourishing prescriptions gradually appeared. Most of them were presented in the form of medicinal diet, such as Zhang Zhongjing’s "Pig Skin Soup", which was made of fresh pigskin, white honey and white powder, but the appearance of a large number of food-nourishing prescriptions had to wait until the Tang and Song Dynasties.

　　Fourth, the application of food and nutrition

　　Before Sun Simiao put forward the theory of "dietotherapy" in Tang Dynasty, the content of diet recuperation in China was mainly manifested in food support. So, what were the main applications of food support before the Tang Dynasty?

　　First of all, of course, in the daily diet guidance, a reasonable diet is the application of food support.

　　Secondly, it is mainly used in the rehabilitation stage after treatment. As the saying in Neijing says, "Eat and nourish everything", after the sixth, seventh, eighth and ninth diseases are removed, the recovery of the body is promoted by eating and nourishing. According to modern theory, on the one hand, it relies on its own immunity to fight against external evils, on the other hand, reasonable food and nutrition itself has a certain function of "replenishing essence and qi" to strengthen its own immunity, and a combination of the two can promote the recovery of the body. This application of food nutrition can effectively avoid the harm to human body in the process of drug use and prevent the occurrence of over-medical treatment, which is especially worth learning from. Of course, the choice of food and support depends on the specific situation.

　　Thirdly, feeding and nourishing is an important way to cure the disease before it happens. Since reasonable food and nutrition can play an effective role in "replenishing essence and qi", the body will naturally be less prone to illness.

　　Before the Tang Dynasty, food support was still in the stage of enlightenment and growth. The author believes that food support is not so much technology as thought and culture. In the Tang Dynasty, Sun Simiao, a famous doctor, effectively inherited and carried forward the thought and culture of food support, and innovatively put forward the theory of "food treatment". Subsequently, a large number of dietotherapy monographs and prescriptions appeared, marking the gradual transition of food support culture from the enlightenment and growth stage before the Tang Dynasty to the development, maturity and prosperity stage.

On September 20th, East China Medicine announced that its long-acting glucagon-like peptide -1(GLP-1) receptor agonist Smegrutide injection phase III clinical trial had completed the first patient enrollment and administration. This is a multi-center, randomized, open and parallel controlled phase III clinical study. The main purpose is to demonstrate the equivalence of blood glucose control between the experimental drug Smegliclade injection and the control drug Smegliclade injection (Novotel) after 32 weeks of treatment in type 2 patients with poor blood glucose control after metformin treatment. According to the Insight database, the trial registration was announced on August 2 this year.

Test registration and historical time axis

Coincidentally, on September 18th, Unacon’s Smegliptide Injection just started its clinical trial (registration number: CTR20232854).

Registration of clinical trials of stone drugs

As a super blockbuster with annual sales of more than 10 billion dollars, smeagoutide is also competing among domestic enterprises. With the continuous advancement of clinical progress, the competition pattern is becoming more and more intense. The data show that there are as many as 12 smeagoutide similar drug projects involving domestic enterprises, and 6 of them are in phase III clinical stage.

Phase III clinical phase Smegliptide biological analogues developed by domestic enterprises.

The patent of smeagoutide in China will expire in 2026. At that time, the listing of similar drugs of smeagoutide will face huge market opportunities. In addition to the diabetes market, domestic drugs are also expected to compete with the "slimming medicine" in the 100 billion blue ocean track.

01 GLP-1: Development Potential of Multiple Indications

Smegliptide has 94% sequence homology with human GLP-1, which is one of the important targets for treating diabetes. As the most eye-catching GLP-1 receptor agonist in the world at present, Novo Nordisk’s smeagoutide has achieved a total sales of over 10 billion US dollars in 2022 with its good hypoglycemic and weight-loss effects, and the total sales of smeagoutide in the first half of this year has also reached 9.23 billion US dollars. According to Jost Sullivan’s prediction, the domestic market size of GLP-1 receptor agonists for hypoglycemic is expected to reach 50.1 billion yuan in 2030.

Judging from the approved indications, smeagoutide can reduce blood sugar by stimulating insulin secretion and reducing glucagon secretion, and at the same time significantly reduce the risk of major cardiovascular events (MACE) in patients with type 2 diabetes. It has been clinically approved for blood sugar control and weight loss in patients with type 2 diabetes. In addition, smegliptide is also a heavy player in the field of weight loss. The indications for obesity or overweight of novonorgestrel injection were approved by FDA in June 2021 and EMA in January 2022. Up to now, although the indications have been declared, they have not been approved in China.

Progress in the Approval of Smegliptide in Major Regions of the World

Smegliptide has great market potential in the field of weight loss, and the sales growth rate has always doubled. According to the latest semi-annual report, the sales of the drug’s weight loss indication (Wegovy) was 12.081 billion Danish kroner (about 1.781 billion US dollars), up 367% year-on-year. Moreover, due to the shortage of production capacity, Novo Nordisk also stopped advertising some of the weight-loss products of Smeagol in the United States in May this year. From another perspective, this shows that the current achievements have not reached the real strength of Smeagol’s "full firepower".

Not only that, but also in other diseases, Smegliptide has many possibilities to explore and treat. For example, in nonalcoholic steatohepatitis (NASH), it has been found that GLP-1 can reduce hepatic steatosis, hepatocyte injury and glucose output after combining with hepatic cell receptors, and reduce the inflammatory reaction and fibrosis of hepatocytes in NASH, which has the potential to treat NASH and is expected to fill the clinical vacancy of drugs for NASH diseases. In the field of Alzheimer’s disease (AD), in recent years, it has been found that GLP-1 may enhance aerobic glycolysis and reduce oxidative phosphorylation by activating PI3K/Akt pathway, and can alleviate the decline of astrocyte glycolysis induced by Aβ, which plays a role in neuroprotection and energy regulation therapy. A corresponding phase III clinical trial is being explored (registration number: NCT05891496). The step-HFpEF trial of smegliptide in treating patients with heart failure with preserved ejection fraction (hfpef) has entered the third phase. The results show that smegliptide can significantly improve the symptoms related to heart failure and exercise ability compared with placebo. In addition, some studies have found that smegliptide has cardiovascular protection, which reduces the risk of major adverse cardiovascular events (MACE). Under the background of "involution" of hypoglycemic and weight-reducing indications, other indications of smeagoutide will be explored, and in the future, the market space of smeagoutide may usher in another outbreak.

02 East China, Cinda, Hengrui … Domestic enterprises are sprinting.

From biologically similar drugs to innovative drugs, from single target to three targets, from injection to oral administration … domestic enterprises are also blocking the potential track in all directions.

1. East China Medicine: Wide layout and fast progress.

Among domestic enterprises, the layout of East China Medicine in GLP-1 field is excellent in comprehensiveness and leadership. In the field of weight loss, GLP-1 product lines covering oral dosage forms, injections and other dosage forms, including long-acting and multi-target global innovative drugs and biologically similar drugs, have been established, including the marketed liraglutide injection. The products under research include a variety of products, such as the biosimilar drug Smegliptide Injection, the global innovative oral small molecule GLP-1 receptor agonist HDM1002, the double-target agonists HDM1005 and SCO-094, and the long-acting triple-target agonist DR10624, so as to realize the all-round layout of GLP-1 with single target, double target, triple target and oral small molecules. Based on the advantages of the existing pipeline, Huadong Pharmaceutical indicated that it will continue to explore innovative projects related to GLP-1, expand the related indications such as lipid lowering and NASH, and continue to develop innovative drugs with higher bioavailability and more clinical advantages. Liraglutide, which is the first to be listed, is a medical insurance product. According to the documents exchanged by investors, the online work in more than 20 provinces in China has been completed, and it is expected that the online work in all provinces will be completed in September. The off-campus market is also the main sales channel, and offline pharmacies are expected to achieve the coverage of more than 30,000 chain retail pharmacies in the third quarter of this year. In the research product pipeline,The clinical trial of GLP-1R/GCGR/FGF21R long-acting triple-target agonist DR10624 for weight management of overweight or obese people was approved by CDE in July. In China, East China Medicine also submitted DR10624 for IND of severe hypertriglyceridemia in August this year. Abroad, in July, 2023, DR10624 completed the first subject administration in the phase I multiple incremental dose administration (MAD) clinical trial for the treatment of obesity in New Zealand. GLP-1R/GIPR double-target long-acting polypeptide agonist HDM1005 has entered the research stage of IND. At present, the project is progressing smoothly, and it is expected to submit an IND application in early 2024. HDM1002, a small molecule GLP-1 receptor agonist, has been reported in both China and the United States. In May 2023, its indication for type 2 diabetes was approved for clinical use in China, and the first trial was completed in June. The indication for overweight or obesity of HDM1002 tablets was also approved in September in China.

2. Cinda Bio’s next performance take-off point: Masidopeptide.

As early as August 2019, Cinda reached a cooperation with Lilly, and introduced GLP-1R/GCGR dual agonist Masculitide (IBI362).

Masidopeptide equity flow chart

At present, Cinda has laid out the indications for type 2 diabetes and obesity of Masculitide in China, and both of them have been promoted to phase III clinical practice. Among similar products in China, the progress is the fastest. The results of phase II clinical study showed that among the overweight or obese subjects in China, the weight of the patients decreased by 11.57% after 24 weeks of continuous administration of 6.0mg of Mastopeptide. And compared with placebo, it can bring 12.6% weight loss. In addition, among the obese patients who need surgical treatment, after 24 weeks, the average weight loss of the group using 9mg of marsden reached 15.4% and the weight loss was 14.7kg.

Results of Phase II Clinical Trial of Masculitide

The two phase III clinical codes of type 2 diabetes are DREAMS-1 and DREAMS-2 respectively, and the latter is a head-to-head clinical trial of dulaglutide; The obesity phase III clinical trial code is GLORY-1. According to the Insight database, at present, 83% of patients in DREAMS-1 have been enrolled, while the progress of GLORY-1 has been 100%.

Phase III clinical trial initiated by IBI362

Cinda said that it is expected to submit the listing application of Mastopeptide from late 2023 to early 2024. In addition to type 2 diabetes and obesity, Masculitide has also been approved for clinical use in NASH, and the corresponding research on NASH will be started soon. The listing of Mastopeptide in China will also provide Cinda with the second performance take-off point after PD-1 cindilizumab, and support Cinda to achieve the goal of 20 billion revenue in the next 4-5 years.

3, Hengrui Pharma: dual agonists, oral small molecules, compound preparations …

At the GLP-1 circuit, Hengrui’s layout can also be described as comprehensive. According to the layout of GLP-1/GLP-1R target enterprises, Hengrui is also among the TOP5.

Number of GLP-1R domestic enterprises’ target layout projects TOP5

Screening [target] is GLP-1/GLP-1R, excluding inactive and inactive projects for more than 3 years; Only new, improved and similar drugs are counted.

With regard to the hot GLP-1 dual-target hypoglycemic agent, Hengrui is researching GLP-1R/GIPR dual agonist HRS 9531, which has just been approved for obesity clinic in May, and has started phase II clinical research and development. In addition, Hengrui also has a GCGR antibody /GLP-1 fusion protein SHR-1816, which has also progressed to clinical stage I. In the field of small molecule oral medicine, Hengrui has HRS-7535, which has started Phase II clinical practice. In the field of compound drugs, Hengrui’s HR17031 is a GLP-1/ insulin compound drug.

Hengrui GLP-1 new drug

END

Source | Insight database

BYD’s situation in 2024, I don’t think I need to introduce it to you too much. It was far ahead of other domestic car companies throughout the year and successfully ranked among the top five in the world. 2024 is so successful, what is BYD going to do in the next 2025, and what new cars will it launch? Today, Xiaobian takes you to know in advance.

summer

Features: more people-friendly and mature

The first one is BYD Summer, which will go on sale on January 8th. This car can be regarded as a more people-friendly D9.

In the design part, on the basis of "Dragon Beauty", it adds a lot of luxurious and practical elements, such as a large-area "Long Lin Armor" net, a domineering body with a length and width of 5145x1970x1805mm (wheelbase of 3045mm), a warm home interior layout, independent two-row seats and three-row seats that can be folded and leveled electrically.

In the power part, the new car is equipped with a 5th-generation DM-i plug-in system consisting of a 1.5T engine (110kW) and a drive motor (200kW), with a maximum battery life of 145km. In addition, the new car will also come standard with the "Eye of God" advanced intelligent driving assistance system. As far as strength is concerned, BYD can play well in summer. If the price (pre-sale price of 300,000 yuan) can be a big surprise when it goes public, it should be no problem to sell it.

Sea lion 07DM-i&DM-p

Features: new model, first equipped with new DM-P.

Although the name of Sea Lion 07DM-i&DM-p is similar to that of Sea Lion 07 EV, they are actually not a mixed version, but a version of BYD Tang’s Ocean Net. Of course, they can also be said to be the new frigate 07.

Sea lion 07

Frigate 07

In the front part, the new car uses the latest design of ocean series models, with rounded headlights and closed air intake grille, and the inductance is sufficient. The side shape of the car body is the same as that of the current frigate 07, equipped with a hidden door handle, except that the front fender is equipped with a side rear camera and the length of the car is increased by 60mm (the width, height and wheelbase are the same as those of the frigate 07); The tail adopts a new style of rear spoiler and rear surround design, and the taillight is also a new style.

In terms of power, the DM-i version is the same as the new Tang DM-i, using the latest 5-generation DM technology, but the DM-p version is one step ahead of BYD Tang, with the latest 1.5T engine and 200kW and 150kW motors.

It is worth mentioning that Sea Lion 07DM-i&DM-p also declared the version with unmanned engine room, and provided the watchtower lidar (optional), which means that this car is complete by land, sea and air.

It is worth mentioning that another car in BYD’s "warship" series is also going to be renamed like frigate 07, but it is merged into the family and becomes. In addition to the name change, the new car has also changed its design, using the 5 th generation DM technology, and it should be listed together with the new Qin PLUS.

Sea lion 06EV

Features: Song PLUS EV of Ocean Network?

It is a new BYD car with spy photos recently. According to the planning and naming rules of BYD’s new car, the new car is probably called Haishi 06 EV, which is the "Song PLUS EV" of Ocean Net.

Sea lion 06 EV

From the spy photos, the new car will adopt a "U" headlight design similar to the Sea Lion 07 EV, the body will be equipped with a semi-hidden door handle design, and the tail will be in line with the Sea Lion 05 DM-i with a penetrating taillight design.

In the interior part, the new car continues the family-style design style of BYD Ocean Network, and is equipped with a four-spoke steering wheel, an LCD instrument and a suspended central control panel. The central island platform adopts layered design, and the electronic gear handle is a common pick shape of the ocean network. As for power, size, etc., there is no information disclosure at present.

Compared with Song PLUS DM-i, the presence of Song PLUS EV is obviously lower, but its sales volume is also more than 10,000 units, so can it be copied successfully when it comes to Sea Lion 06EV?

Sea lion 05EV

Characteristics, marine network

Looking at the name here, do you think it is the pure electric version of Sea Lion 05DM-i? It would be a big mistake to think so. From the specific information, this car is more like the "Yuan PLUS" of the ocean network.

Sea lion 05EV

Yuan PLUS

In terms of appearance, the front face of the new car adopts a closed design, and the rounded headlights on the upper part are connected through the light strips. After matching with the vents on both sides, it looks quite fashionable. As for the side and tail of the car, it is simple, with semi-hidden door handles, wide wheel eyebrows, penetrating taillights and other elements.

It is worth mentioning that although the measurements (length, width and height) of the new car can’t catch up with Shanghai Lion 05DM-i, it is obviously superior to Yuan PLUS. In addition, it also provides more options for the power part (150kW for all the yuanplus motors), with 140kW and 160kW.

Tang l

Features: BYD Tang Chao evolution, or competition.

Although Tang L is still in the stage of spy photos, it should be impossible to go public in 2025.

Judging from the latest spy photos, the new car will probably use a more inductive Longyan design like Tang EV, but the bumper will adopt a layered design with more elements. It is worth mentioning that the new car also exposed the lidar and unmanned cabin, and the level of intelligent driving and playability should be greatly improved.

The side and tail of the car are relatively straight and wide, and the length of the car is expected to be 5 meters+level. The interior, on the other hand, is a conventional suspended layout, but the gear shift has become a design with arms. As for the power and chassis, there is not much information at present, but the E platform 3.0, the 5th generation DM, the former McPherson+the rear five-link suspension combination, and Yunqi -C should not be absent from it.

With such sufficient materials, it’s a pity that the new Tang DM-i’s "minor changes" can be made up in Tang L.

Han l

Features: BYD is completely Chinese, competing with SU7,

Although it is also a spy stage, it should be officially listed in 2025 like Tang L. Considering that the rejuvenation speed of Han is generally faster than that of Tang, Han L will be listed earlier.

Judging from the spy photos exposed, Han L is not only an enlarged version of Han, but also uses hidden door handles, large-size double five-spoke rims, ecstasy-raising waistlines, full and round body (similar), slender "Chinese knot" taillights, and sports encirclement, etc., which is more advanced.

The interior part is the family’s suspended layout, which is not amazing, but the chassis is said to use the combination of front and rear double wishbone suspension and rear five-bar suspension, and may be equipped with car refrigerator, laser radar, DiPilot 300 "Eye of God" high-order intelligent driving system and other configurations. The power, e-platform 3.0, fifth-generation DM, etc., should not be absent, and may be strengthened.

With such product strength, do you think it can be rigid and Tesla Model 3?

Han l interior spy photos

Hanneishi

Equation Leopard Titanium 3

Features: pure electric "big toy"

Different from the hard-core off-road route introduced by Equation Leopard, the new off-road route is more about pure electric home.

Pure electricity should not need to be expanded too much, just look at its dual motors (front motor 110kW, rear motor 200kW) and four-wheel drive power (000 4.9 seconds). For home use, it is more because it uses a car body than a car body with a girder. And in terms of space construction, it is also built in a big place, so that titanium 3 has a wheelbase of 2745mm (positioning medium-sized SUV) on the basis of 4605/1900/1720mm length/width/height.

As for off-road, it is mainly reflected in its very tough design. The thick bumper, compact body, external wheel eyebrows, external spare tire, etc. all make it look very simple and fighting. It is worth mentioning that the top model of titanium 3 will also be equipped with drones, providing unique aerial photography and entertainment functions, which can make the car more interesting.

Personalized pure electric square boxes are really hot recently, such as Chery’s iCAR series and the arrival of Equation Leopard Titanium 3. Is it possible to further detonate this market? It is worth looking forward to.

Tengshi N9

Features: Easy Tripartite Blessing, Shenzhen Bay

Recently, there is a stepping stone called Range Rover, and the new full-size SUV basically has to step on it! And, it is the car that is ready to do it. Its key words are easy tripartite, full-size, and the flagship of Tengshi.

Don’t think that if you use Easy Tripartite, Tengshi N9 will be very ordinary if you reuse it. Compared with Z9, if you put it in the full-size SUV market, this system can still kill most of your peers. Thousands of horsepower, compass turning around, intelligent crab walking, etc., it can be easily completed, and the overall flexibility is not inferior to that of a compact SUV.

Inside the car, it’s Tengshi’s family-style design, with low-cost materials, a sense of ceremony and high-class, refrigerators, color TVs, big sofas, etc., all of which are fully equipped, and the sense of luxury is directly full. As for the intelligent driving, it is also the same model as Tengshi Z9, with the eye of the god with laser radar.

At present, most of the self-selling 500,000-class SUVs are doing quite well. For example, now that they are coming to the N9 with more "independent" technology, the opportunity should not be small.

Look up at U7

Features: the first ride is Yunqi -Z, and the price is one million.

Equation Leopard and Tengshi brands are all new. How can we expect fewer brands? So the D-class executive car -U7 is coming.

Design this piece, different people have different opinions, but in technology this piece, it is completely far ahead. The new car not only has the unique secret of looking up-Easy Sifang (1,300 horsepower, 2.9 seconds of zero acceleration), but also is equipped with the latest Yunqi -Z developed by BYD. This system not only helps the car to realize full digital adjustment of body posture in three directions and six degrees of freedom, but also can recover energy at work and supply power for the car.

As for the size and luxury, it is completely in line with the D-class luxury car, with a length/width/height of 5265/1998/1517mm and a wheelbase of 3160mm (pure electric version); BYD’s top high-level intelligent driving; Luxurious configuration, materials, very willing to spend money.

The car is a good car, but at present, the million-class luxury car market is very lively, and there are still new cars. Can you get a piece of U7?

Write it at the end

In addition to these brand-new models, other cars sold by BYD will also be listed in 2025, such as new models and new Qin PLUS, which have all been declared.

There are many new cars, and the models are changed quickly. To what extent will BYD’s sales be hit by this wave of cars? From more than 4 million in 2024 to more than 5 million? If the hurricane continues, will Toyota, the world’s number one, be pulled down by it? It is worth looking forward to.

(This article is only the author’s personal opinion and does not represent the position of Heche Society.)

Tianyancha App shows that on April 27, 2025, the announcement of the procurement results of security services of GAC Hino Automobile Co., Ltd. was released. This procurement was organized by Guangzhou Zhicheng Property Service Co., Ltd., and Zhenyuan Tewei Security Group Co., Ltd. Guangzhou Branch, Guangdong Xinnuoan Security Service Co., Ltd. Guangzhou Branch and Guangdong Dedun Security Service Co., Ltd. were invited to participate in the bidding. In the end, Guangdong Dedun Security Service Co., Ltd. successfully won the bid, and the transaction amount was 979,440.00 yuan. The project is located in Guangdong Province, and the procurement content is security services.

Disclaimer: The content of this article is automatically generated by an open intelligent model for reference only.

From March 1, 2023

A number of important new regulations will be formally implemented.

The new regulations cover medical care, taxation, education and other fields.

Let’s get to know ↓ ↓ ↓

01

The implementation of the new national medical insurance drug list!

The National Drug List of Basic Medical Insurance, Work Injury Insurance and Maternity Insurance (2022) issued by the National Medical Insurance Bureau and Ministry of Human Resources and Social Security has been officially implemented since March 1, 2023. The new version of the national medical insurance drug list added 111 drugs, and the average price of newly admitted drugs through negotiation and bidding dropped by 60.1%. The total number of drugs in the new national medical insurance drug list reached 2967, including 1586 kinds of western medicine and 1381 kinds of Chinese patent medicine; There are still 892 kinds of Chinese herbal pieces without adjustment.

02

These six tax certification items are subject to the notification commitment system!

Announcement on Further Implementing the Informing Commitment System for Some Tax Certificates issued by State Taxation Administration of The People’s Republic of China, since March 1, 2023, the informing commitment system has been implemented nationwide for six tax certificates listed in the catalogue, including: national comprehensive fire rescue vehicle certificate, public bus and tram vehicle identification form, special vehicle certificate, family member information certificate, family sole living room certificate, operator identity certificate of individual industrial and commercial households, and partnership identity certificate of partnership partners.

03

The newly revised "National Management Measures for Work-for-Welfare" is implemented!

The National Development and Reform Commission has comprehensively revised the Measures for the Administration of National Work-for-Relief promulgated and implemented in 2014, which has been officially promulgated recently and will be implemented on March 1, 2023. The "Administrative Measures" clarify the management system and working mechanism of "central planning, overall responsibility of the province, and implementation by cities, counties and townships", clarify the implementation scope, beneficiaries, construction areas and relief modes of the work-based relief policy, emphasize the policy objectives of paying labor remuneration to the people involved in the project construction and developing skills training, further improve the specific requirements of the work-based relief investment plan, special fund project management, supervision and inspection, and add the government.

04

New regulations on quality and safety supervision of food-related products are coming!

The Interim Measures for Quality and Safety Supervision and Management of Food-related Products issued by the General Administration of Market Supervision shall come into force on March 1, 2023. The Measures stipulate the main responsibilities of producers and sellers of food-related products and the specific requirements for the control of the whole production process. Producers of food-related products should establish systems such as raw and auxiliary materials control, key production links control, inspection control and transportation delivery control, and sellers should establish the incoming inspection system of food-related products. At the same time, the quality and safety traceability system, recall management system and label management system of food-related products were clarified.

05

National Medical Products Administration has new regulations to implement the main responsibility for the quality and safety of drugs and cosmetics!

In order to implement the main quality responsibility of drug marketing license holders, according to the Drug Administration Law of People’s Republic of China (PRC) and other laws and regulations, National Medical Products Administration formulated the Provisions on the Supervision and Administration of Drug Marketing License Holders Implementing the Main Quality and Safety Responsibility of Drugs, which came into effect on March 1, 2023.

In order to urge enterprises to implement the main responsibility of cosmetic quality and safety, strengthen their awareness of the responsibility of cosmetic quality and safety, standardize the management behavior of cosmetic quality and safety, and ensure the quality and safety of cosmetics, according to the Regulations on the Supervision and Administration of Cosmetics, the Measures for the Administration of Cosmetics Registration and Filing, the Measures for the Supervision and Administration of Cosmetics Production and Operation, and the Standards for the Administration of Cosmetics Production Quality, National Medical Products Administration organized and formulated the Regulations on the Supervision and Administration of Enterprises Implementing the Main Responsibility of Cosmetics Quality and Safety, which came into effect on March 1, 2023.

06

Measures for the Administration of the Protection of Consumer Rights and Interests of Banks and Insurance Institutions

The Administrative Measures for the Protection of Consumers’ Rights and Interests in Banking and Insurance Institutions, formulated and promulgated by China Banking and Insurance Regulatory Commission, China, came into force on March 1, 2023. The "Administrative Measures" clarify that bank insurance institutions bear the main responsibility of protecting the legitimate rights and interests of consumers, and consumers have the obligation to be honest and trustworthy. Standardize the operation behavior of bank insurance institutions and protect consumers’ eight basic rights, including standardizing product design, information disclosure and sales behavior, prohibiting misleading propaganda, forced tying and unreasonable charges, and protecting consumers’ right to know, independent choice and fair trade. Strict behavior supervision requirements, clear unified standards and unified discretion for similar businesses and similar subjects, and crack down on chaos and behaviors that infringe on consumer rights and interests according to law.

07

14 kinds of new pollutants are listed in the key control list!

The Ministry of Ecology and Environment, together with relevant departments, issued the List of New Pollutants under Key Control (2023 Edition), which will take effect on March 1, 2023. New pollutants refer to toxic and harmful chemicals discharged into the environment, which have the characteristics of biotoxicity, environmental persistence and bioaccumulation, and pose great risks to the ecological environment or human health, but have not been brought into management or the existing management measures are insufficient. According to the environmental risks of toxic and harmful chemicals, combined with the actual supervision, and after technical feasibility and economic and social impact assessment, the list clearly defines 14 kinds of key new pollutants such as perfluorooctane sulfonic acid and its salts, perfluorooctane sulfonyl fluoride, perfluorooctanoic acid and its salts and related compounds, decabromodiphenyl ether and other environmental risk control measures such as prohibition, restriction and discharge restriction.

08

Information technology products using the national common language should conform to the specifications!

The Ministry of Education promulgated the Regulations on the Administration of the Use of National Common Language and Characters of Information Technology Products, which requires that information technology products use national common language and characters, and should conform to the language and characters standards promulgated by the state. The use of the national common language in digital and online publications shall conform to the standards of Chinese Pinyin, Putonghua pronunciation, standardized Chinese characters, modern Chinese word forms, punctuation marks and digital usage. If it is necessary to use Chinese dialects, traditional Chinese characters and variant Chinese characters, it shall comply with the relevant provisions of the Law of People’s Republic of China (PRC) on National Common Language and Characters. At the same time, it emphasizes the service orientation, requiring related products to provide users with functions such as verbal information prompt and feedback, and emphasizing that products for the disabled, the elderly and children should take care of their special needs. The Management Regulations will come into force on March 1, 2023.

09

Implementation of "Measures for the Management of Water and Soil Conservation Schemes for Production and Construction Projects"

In order to standardize and strengthen the management of water and soil conservation schemes for production and construction projects, and to prevent and control soil erosion that may be caused by production and construction projects, the Ministry of Water Resources revised and promulgated the Measures for the Management of Water and Soil Conservation Schemes for Production and Construction Projects, adjusted the compilation scope of water and soil conservation schemes for production and construction projects according to the relevant requirements of the Law on Water and Soil Conservation, defined the responsibilities of production and construction units, refined the regulations on the change of water and soil conservation schemes, strengthened the requirements for monitoring, supervision and inspection of water and soil conservation, and made provisions for "building without approval", "investing before inspection". The "Management Measures" came into effect on March 1, 2023, and the "Regulations on the Administration of Compilation and Approval of Soil and Water Conservation Plans for Development and Construction Projects" issued by the Ministry of Water Resources on May 30, 1995 was abolished at the same time.

10

"Management Measures for Quality Inspection of Construction Projects" is implemented!

The Measures for the Administration of Construction Engineering Quality Inspection formulated by the Ministry of Housing and Urban-Rural Development shall come into force on March 1, 2023, and the Measures for the Administration of Construction Engineering Quality Inspection promulgated by the former Ministry of Construction on September 28, 2005 (DecreeNo. 141st of the Ministry of Construction) shall be abolished at the same time. The Management Measures further strengthens the management of construction project quality inspection from many aspects, such as adjusting the scope of construction project quality inspection, strengthening the dynamic management of qualifications, standardizing construction project quality inspection activities, improving the responsibility system of construction project quality inspection, improving the level of digital application, strengthening government supervision and management, and increasing penalties for violations of laws and regulations, so as to maintain the market order of construction project quality inspection and standardize construction project quality inspection behavior.

Producer: Lu Yi

Producer Zheng Hong?

Editor Zheng Liheng

Editor Tan Yan